Dr Itay Wiser

Botox vs Fillers: What’s the Difference?

Botox relaxes; fillers restore. Botox and the other neuromodulators calm the small muscles that crease the skin with expression, so frown lines, forehead lines and crow's feet soften. Dermal fillers add volume where the face has lost it or lacks definition: lips, cheeks, jawline, under the eyes. One treats lines made by movement; the other treats shape and volume. Many patients need both, and Sarah Walner, PA-C often combines them in one visit.

Botox and other neuromodulatorsDermal fillers
How it worksRelaxes the muscle that makes the lineAdds volume beneath the skin
TreatsFrown lines, forehead lines, crow's feet, bunny lines, chin dimpling, jaw slimmingLips, cheeks, jawline, under-eye hollows, folds around the mouth, temples, hands
Result appearsWithin days, full at about two weeksImmediately, settled in about two weeks
LastsA few monthsSeveral months to a year or more by area
DowntimeMinimal; possible bruiseSwelling and possible bruising for a few days
ReversibleWears offHyaluronic acid filler can be dissolved

Results and how long they last vary by patient, area and product.

How to tell which you need

Make the expression. If the line appears when you frown, raise your brows or smile and softens when you relax, a neuromodulator is the tool. If the concern is there at rest, a hollow cheek, a thin lip, a flat jawline, a deep fold, it is volume or structure, and filler is the tool. If a line is there at rest and deepens with expression, it may need both.

When patients need both

Expression lines and volume loss arrive together in most faces from the late thirties on. A common combination is a neuromodulator for the upper face (frown and forehead lines, crow's feet) and filler for the mid and lower face (cheeks, lips, folds). Treating cheeks with filler often softens the folds below them, so the plan is built from the top and the structure first.

Sarah's approach to combining

Conservative doses, structure before folds, and a review two weeks later before adding more. A first visit is often a neuromodulator plus one filler area, with the rest staged, so the face changes gradually and never looks done. The Botox and fillers in NYC page covers neuromodulators, dermal fillers in NYC covers filler by area, and the pricing guide explains how each is priced.

Questions patients ask

Can Botox fill in wrinkles?

No. Botox relaxes the muscle that makes a line; it does not fill the line. A deep static line that remains when the face is at rest may need filler, a peel, or both.

Can fillers stop expression lines?

No. Filler adds volume; it does not relax muscle. Lines made by frowning or squinting keep forming unless the muscle is treated.

Which should I start with?

If your concern is lines that appear when you make an expression, start with a neuromodulator. If it is hollowing, flattening or lost definition, start with filler. If both, many patients do both in one visit.

Which lasts longer?

Fillers generally last longer than neuromodulators, by area and product. Results and how long they last vary by patient, area and product.

Find out which you need

At the free virtual consultation Sarah watches your face move and at rest and tells you which tool fits, or whether both do.


About the author. Sarah Walner, PA-C, joined WiserMD in 2024 after receiving her Master of Science in Physician Assistant Studies from Midwestern University. Before her physician assistant studies, she received her Bachelor of Science in Human Development from the University of Wisconsin-Madison. After becoming a certified physician assistant in 2024, Sarah began her career as a plastic surgery PA with Dr. Wiser. She has assisted in a wide range of cosmetic surgical procedures, including body contouring, breast surgery, facelift and blepharoplasty. Sarah is also the lead injector at WiserMD, specializing in natural, non-surgical facial rejuvenation with Botox, filler and microneedling. Every treatment plan is medically reviewed by Dr. Itay Wiser, Associate Clinical Professor of Surgery at Mount Sinai Elmhurst Hospital.

Medical disclaimer: This page is for general education and does not replace an individual consultation. Results and longevity vary by patient and product.